GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UCEC | cis | rs9473555 | 1 | rs1141321 | chr6:49412433 | MUT | chr6:49398994-49431031:- | 0.41 | 6.83 | 1.93E-10 | Folate pathway vitamin levels |
| UCEC | cis | rs9815354 | 1 | rs114960066 | chr3:41882323 | ULK4 | chr3:41288091-42003660:- | 0.52 | 6.33 | 2.61E-9 | Diastolic blood pressure |
| UCEC | cis | rs60843830 | 1 | rs114976176 | chr2:264621 | SH3YL1 | chr2:218138-264810:- | -0.46 | -6.42 | 1.61E-9 | Spherical equivalent (joint main effects and education interaction) |
| UCEC | cis | rs60843830 | 1 | rs11553746 | chr2:272203 | SH3YL1 | chr2:218138-264810:- | -0.5 | -6.58 | 7.34E-10 | Spherical equivalent (joint main effects and education interaction) |
| UCEC | cis | rs950169 | 1 | rs11638297 | chr15:84782417 | LOC388152 | chr15:84867600-84898920:- | -0.48 | -4.98 | 1.69E-6 | Schizophrenia |
| UCEC | cis | rs950169 | 1 | rs11638394 | chr15:84778928 | LOC388152 | chr15:84867600-84898920:- | -0.43 | -4.48 | 1.44E-5 | Schizophrenia |
| UCEC | cis | rs11645002 | 1 | rs11645002 | chr16:20617841 | ACSM1 | chr16:20634559-20709066:- | 0.41 | 4.7 | 5.74E-6 | Urinary metabolites |
| UCEC | cis | rs9894429 | 1 | rs11651264 | chr17:79576394 | TSPAN10 | chr17:79609349-79615778:+ | -0.66 | -8.57 | 1.11E-14 | Eye color traits |
| UCEC | cis | rs9894429 | 1 | rs11652797 | chr17:79574124 | TSPAN10 | chr17:79609349-79615778:+ | 0.66 | 8.41 | 2.74E-14 | Eye color traits |
| UCEC | cis | rs9309473 | 1 | rs11674602 | chr2:73723185 | ALMS1P | chr2:73872046-73912692:+ | 0.53 | 6.14 | 6.87E-9 | Metabolite levels |
| UCEC | cis | rs1167827 | 1 | rs1167827 | chr7:75163169 | PMS2L3 | chr7:75137070-75157418:- | -0.55 | -6.65 | 5.04E-10 | Body mass index |
| UCEC | cis | rs9309473 | 1 | rs11689392 | chr2:73622026 | ALMS1P | chr2:73872046-73912692:+ | 0.54 | 6.42 | 1.64E-9 | Metabolite levels |
| UCEC | cis | rs10935120 | 1 | rs11708531 | chr3:134224902 | ANAPC13 | chr3:134196547-134204865:- | 0.4 | 4.62 | 8.08E-6 | Height |
| UCEC | cis | rs10461617 | 1 | rs11739344 | chr5:56111087 | C5orf35 | chr5:56205103-56213010:+ | 0.55 | 5.94 | 1.86E-8 | Type 2 diabetes |
| UCEC | cis | rs1577917 | 1 | rs11758849 | chr6:86708262 | SNHG5 | chr6:86386726-86388451:- | -0.43 | -5.18 | 6.97E-7 | Response to antipsychotic treatment |